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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
E2F1
All Species:
12.42
Human Site:
S285
Identified Species:
22.78
UniProt:
Q01094
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q01094
NP_005216.1
437
46920
S285
S
S
E
N
F
Q
I
S
L
K
S
K
Q
G
P
Chimpanzee
Pan troglodytes
XP_524538
437
47536
Y290
T
E
D
N
L
Q
I
Y
L
K
S
T
Q
G
P
Rhesus Macaque
Macaca mulatta
XP_001103717
502
53768
S350
S
S
E
T
F
Q
I
S
L
K
S
K
Q
G
P
Dog
Lupus familis
XP_542963
571
61192
I419
D
S
S
E
T
F
Q
I
S
L
K
S
K
Q
G
Cat
Felis silvestris
Mouse
Mus musculus
Q61501
430
46305
Q278
V
D
S
S
E
T
F
Q
I
S
L
K
S
K
Q
Rat
Rattus norvegicus
Q62814
300
33206
P156
S
G
T
Q
L
E
V
P
I
P
E
M
G
Q
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515449
468
50133
I308
T
Y
Q
D
I
R
A
I
S
N
F
R
E
Q
T
Chicken
Gallus gallus
Q90977
403
43534
F259
V
S
D
P
G
E
A
F
Q
V
S
V
R
S
T
Frog
Xenopus laevis
NP_001090608
426
47125
S276
P
S
E
A
Y
Q
M
S
L
K
S
T
Q
G
P
Zebra Danio
Brachydanio rerio
NP_001074097
429
46452
D285
E
T
K
L
E
V
P
D
P
K
E
S
L
Q
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27368
805
87442
S623
N
R
N
H
S
N
H
S
N
H
S
N
H
S
S
Honey Bee
Apis mellifera
XP_396223
416
46049
P272
I
M
A
V
K
A
P
P
E
A
T
L
H
V
P
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001123287
404
44387
H260
R
Y
A
Y
V
T
Y
H
D
I
R
G
I
Q
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.7
86
70.9
N.A.
84.6
23.1
N.A.
39.9
59.9
49.8
37.2
N.A.
20.6
29.7
N.A.
38.4
Protein Similarity:
100
54.4
86.2
72.6
N.A.
88.5
37.9
N.A.
51.2
70
63.3
53.7
N.A.
31.5
46.4
N.A.
54.2
P-Site Identity:
100
60
93.3
6.6
N.A.
6.6
6.6
N.A.
0
13.3
66.6
6.6
N.A.
13.3
6.6
N.A.
0
P-Site Similarity:
100
73.3
93.3
13.3
N.A.
20
26.6
N.A.
40
33.3
80
20
N.A.
26.6
13.3
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
16
8
0
8
16
0
0
8
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
8
16
8
0
0
0
8
8
0
0
0
0
0
0
% D
% Glu:
8
8
24
8
16
16
0
0
8
0
16
0
8
0
0
% E
% Phe:
0
0
0
0
16
8
8
8
0
0
8
0
0
0
0
% F
% Gly:
0
8
0
0
8
0
0
0
0
0
0
8
8
31
8
% G
% His:
0
0
0
8
0
0
8
8
0
8
0
0
16
0
0
% H
% Ile:
8
0
0
0
8
0
24
16
16
8
0
0
8
0
0
% I
% Lys:
0
0
8
0
8
0
0
0
0
39
8
24
8
8
0
% K
% Leu:
0
0
0
8
16
0
0
0
31
8
8
8
8
0
0
% L
% Met:
0
8
0
0
0
0
8
0
0
0
0
8
0
0
0
% M
% Asn:
8
0
8
16
0
8
0
0
8
8
0
8
0
0
8
% N
% Pro:
8
0
0
8
0
0
16
16
8
8
0
0
0
0
39
% P
% Gln:
0
0
8
8
0
31
8
8
8
0
0
0
31
39
8
% Q
% Arg:
8
8
0
0
0
8
0
0
0
0
8
8
8
0
0
% R
% Ser:
24
39
16
8
8
0
0
31
16
8
47
16
8
16
16
% S
% Thr:
16
8
8
8
8
16
0
0
0
0
8
16
0
0
16
% T
% Val:
16
0
0
8
8
8
8
0
0
8
0
8
0
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
16
0
8
8
0
8
8
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _